Type 2 Diabetes Mellitus: A Review of Determinants, Pathophysiology, Diagnostics, Management, and Complications
DOI:
https://doi.org/10.58526/jsret.v4i3.809Keywords:
Type 2 diabetes mellitus, Determinants, ManagementAbstract
The prevalence and incidence of diabetes mellitus are both on the rise, making it a continuing problem on a global scale. There are multiple factors that contribute to the development of type 2 diabetes mellitus. The disease is characterized by the presence of both a genetic component and an equally significant environmental component. A process of chronic hyperglycemia is the first step in the development of diabetes mellitus. This hyperglycemia is caused by the inability of pancreatic beta cells to secrete insulin, as well as insulin resistance in the muscles and the liver. Diabetes Mellitus Type 2 that is not treated with either medication will result in a variety of problems, including chronic consequences such as microangiopathy, retinopathy, nephropathy, and macroangiopathy. These complications can be caused by a number of different factors. The determinants, pathophysiology, diagnosis, management, and complications of type 2 diabetes mellitus are all topics that are covered in this study.
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References
Decroli, E. (2019). Diabetes Melitus Tipe 2 (1st ed.; A. Kam, Ed.). Padang: Pusat Penerbitan Bagian Ilmu Penyakit Dalam Fakultas Kedokteran Universitas Andalas. Retrieved from http://repo.unand.ac.id/21867/1/Buku%20Diabetes%20Melitus%20%28Lengkap%29.pdf
Delfina, S., Carolita, I., Habsah, S., & Ayatillahi, S. (2021). ANALISIS DETERMINAN FAKTOR RISIKO KEJADIAN DIABETES MELLITUS TIPE 2 PADA USIA PRODUKTIF. Jurnal Kesehatan Tambusai, 2(4), 141–151. https://doi.org/10.31004/JKT.V2I4.2823
Delfina, S., Carolita Maharani, I., Habsah, S., & Ayatillahi, ta. (2021). Literature Review: Analisis Determinan Faktor Risiko Kejadian Diabetes Melitus Tipe 2 Pada Usia Produktif. Jurnal Kesehatan Tambusai, 2 (4)(4), 141–151. https://doi.org/http://dx.doi.org/10.31004/jkt.v2i4.2823
Dharma Hita, I. P. A., & Pranata, D. (2021). Hubungan Tingkat Kejadian Diabetes Melitus Terhadap Kondisi Hipertensi di Indonesia. Jurnal Sporta Saintika, 6 (2), 132–146. https://doi.org/http://dx.doi.org/10.24036/sporta.v6i2.182
Kemenkes RI. Pedoman Nasional Pelayanan Kedokteran Tata Laksana Diabetes Melitus Tipe 2 Dewasa. , Pub. L. No. HK.01.07/MENKES/603/2020 (2020). https://kemkes.go.id/id/pnpk-2020---tata-laksana-diabetes-melitus-tipe-2-dewasa.
Kemenkes RI BKPK. (2023). Survei Kesehatan Indonesia. Retrieved from https://drive.google.com/file/d/1rjNDG_f8xG6-Y9wmhJUnXhJ-vUFevVJC/view
Nora, P., Gultom, N., Harahap, F., Edi, S., & Sipahutar, H. (2025). Hubungan Antara Jenis Kelamin dan Usia pada Penyakit Diabetes Melitus di Puskemas Kota Medan Tahun 2024-2025. JURNAL BIOSHELL, 14 (1)(1), 142–150. https://doi.org/10.56013/bio.v14i1.3960
PERKENI (2021) Pedoman Pengelolaan dan Pencegahan Diabetes Militus Tipe 2 di Indonesia 2021. Jakarta: PB. PERKENI.
Saputri, R. D. (2020). Komplikasi Sistemik Pada Pasien Diabetes Melitus Tipe 2. Juni, 11 (1)(1), 230–236. https://doi.org/10.35816/jiskh.v10i2.254
Sari, N. N. (2019). HUBUNGAN OBESITAS SENTRAL DENGAN KEJADIAN DIABETES MELLITUS TIPE II. Jurnal Ilmiah Keperawatan Sai Betik, 14(2), 157. https://doi.org/10.26630/JKEP.V14I2.1299
Sari, N., & Purnama, A. (2019). Aktivitas Fisik dan Hubungannya dengan Kejadian Diabetes Melitus. Window of Health: Jurnal Kesehatan, 2 (4), 368–381. Retrieved from https://pdfs.semanticscholar.org/208f/f4320b2530df6527f01a78654248cfd6735c.pdf
Sun, H., Saeedi, P., Karuranga, S., Pinkepank, M., Ogurtsova, K., Duncan, B. B., … Magliano, D. J. (2022). IDF Diabetes Atlas: Global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045. Diabetes Research and Clinical Practice, 183, 109119. https://doi.org/10.1016/J.DIABRES.2021.109119
Widiasari, K. R., Kusuma Wijaya, I. M., & Suputra, P. A. (2021). Diabetes Melitus Tipe 2: Faktor Risiko, Diagnosis, Dan Tatalaksana. Ganesha Medicina Journal, 1 (2), 114–120. https://doi.org/https://doi.org/10.23887/gm.v1i2.40006
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